The main aim of this project is to highlight, on the whole value chain using Romanian sorghum crops as raw material, sustainable biotechnologies applied to convert biomass into biofuels and other biopolymers. The ecological and economic feasibility is caused by the combined utilization of the side-products (bagasse, distillation residues) for cellulosic ethanol and biogas production, and by the obtained digestate which returns as high value fertilizer on the crops land. Sweet sorghum produced in Romania as the main feed stock in an integrated process can serve as a model for a sustainable biorefinery concept. Research in this project will provide scientific results concerning the potential of renewable energy production from agricultural biomass and will find ways to develop sustainable processes of biomass conversion into biorefineries. Several sweet sorghum varieties will be tested. The most original approach in this project is closing the loop in the processing path of agricultural biomass and returning organic matter into soil through digestate. Experimental results will provide essential data that will permit the development of a model of sustainable agro-industrial bioproces, part of the general concept of sustainable development. Obtained results can be transferred in agro-industry as: superior and original use of domestic bioresources, efficiency of biofuels production processes, developing a bioproces to serve as a sustainable agro-industrial model.